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KMID : 1156220070330050379
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Journal of Environmental Health Sciences
2007 Volume.33 No. 5 p.379 ~ p.385
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Immatured Type Uterotrophic Assay for Estrogenicity Evaluation of DEHA
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Park Ki-Dae
Han Beom-Seok
Jeong Ja-Young
Oh Jae-Ho
Cho Wan-Seob
Cho Min-Jung
Choi Mi-Na
Kim Sung-Jun
Kim Seung-Hee
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Abstract
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This study was aimed to investigate the estrogenic activity of Di-(2-ethylhexyl) adipate (DEHA) using immatured type uterotrophic assay. SD rats were treated with DEHA (40, 200, 1000 ㎎/㎏/day), estradiol-3-benzoate (EB) (1 ㎍/㎏/day) as positive control on the assay. In immatured-type uterotrophic assay, relative organ weights of kidney and reproductive organs such as ovary at high-dose group were significantly increased compared to those of vehicle control group. DEHA did not influence the levels of serum FSH and LH, and uterine morphological changes such as luminal epithelial height, myometrial thickness and numbers of uterine gland, and BrdU indices. In these results, there was no significant variation by DEHA treatment, suggesting that DEHA appears not to be a endocrine disrupter with estrogenic activity.
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KEYWORD
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DEHA, immatured type uterotrophic assay, estrogenic activity
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